TAMOXIFEN

Product: 
TAMOXIFEN
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
Nolvadex, Istubal, and Valodex.
Dosages: 
10 mg/20 mg
Unit of Packing: 
Tablet
In treatment of: 
Treatment of Breast Cancer
Adverse Effects: 
1. Nausea 2. Vomiting 3. Diarrhea 4. Leucopenia 5. Thrombocytopenia 6. Elevated liver enzymes 7. Vaginal discharge 8. Irregular menses 9. Amenorrhea 10. Hypocalcaemia 11. Weight gain 12. Increased cholesterol level 13. Bone pain 14. Hot flushes 15. Fluid retention 16. Skin changes 17. Uterine fibroids 18. Hypertriglyceridaemia 19. Thromboembolism
Contraiindication: 
1. Hypersensitivity to the drug 2. Women who are taking coumarin type anticoagulants 3. History of deep vein thrombosis 4. Pulmonary edema 5. Porphyria
Special Precaution: 
1. Leucopenia 2. Thrombocytopenia 3. Monitor patients liver, renal and gynecological functions (in women) regularly.
Interaction: 
Oral anticoagulants: Significant increase in anticoagulant effect requiring careful monitoring of prothrombin time. Bromocriptine: Serum tamoxifen levels are elevated. Cyclophosphamide: Since tamoxifen is a potent inhibitor of cytochrome P450 oxidase it may affect metabolism and excretion of cyclophosphamide.
Servings: 
Oral- Adult- 20-40mg/day in 2 divided doses.

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