TEGASEROD

Product: 
TEGASEROD
Formulary: 
Generic Formulary
Category: 
Gastrointestinal Tract
Sub Group: 
DRUGS ACTING ON COLON & RECTUM
International Brand Name: 
Zelnorn,Zelanac
Dosages: 
2 MG
Unit of Packing: 
Tablets
In treatment of: 
Chronic Idiopathic constipation;Ibs W/ constipation in women
Adverse Effects: 
1. Abdominal pain 2. Diarrhoea 3. Headache 4. Nausea 5. Flatulence 6. Dizziness
Contraiindication: 
1. Hypersensitivity to Tegaserod 2. Severe renal impairment 3. Severe hepatic impairment 4. Bowel obstruction 5. Symptomatic Gall bladder disease 6. Suspected sphincter of Oddi dysfunction
Special Precaution: 
1. Diarrhoea 2. Discontinue the use of medicament if any discomfort occurs
Interaction: 
There was no effect on the pharmacokinetics of digoxin, oral contraceptives, and warfarin. Dextromethorphan: A pharmacokinetic interaction study demonstrated that co-administration of tegaserod and dextromethorphan did not change the pharmacokinetics of either compound to a clinically relevant extent. Dose adjustment of either drug is not necessary when tegaserod is combined with dextromethorphan. Theophylline: Co-administration of tegaserod and theophylline did not affect the pharmacokinetics of theophylline. Dose adjustment of theophylline is not necessary when tegaserod is co-administered. Digoxin: Concomitant administration of tegaserod reduced peak plasma concentration and exposure of digoxin by approximately 15%. Warfarin: No effect of concomitant administration of tegaserod on warfarin pharmacokinetics and pharmacodynamics. Dose adjustment of warfarin is not necessary when tegaserod is co-administered. Oral Contraceptives: No alteration in oral contraceptive medication is necessary when tegaserod is co-administered.
Servings: 
Adult: 12 mg / day in 2 divided doses before meals for 1 - 1

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