DRUGS ACTING ON COLON & RECTUM
International Brand Name:
In treatment of:
Chronic Idiopathic constipation;Ibs W/ constipation in women
1. Abdominal pain
1. Hypersensitivity to Tegaserod
2. Severe renal impairment
3. Severe hepatic impairment
4. Bowel obstruction
5. Symptomatic Gall bladder disease
6. Suspected sphincter of Oddi dysfunction
2. Discontinue the use of medicament if any discomfort occurs
There was no effect on the pharmacokinetics of digoxin, oral contraceptives, and warfarin.
Dextromethorphan: A pharmacokinetic interaction study demonstrated that co-administration of tegaserod and dextromethorphan did not change the pharmacokinetics of either compound to a clinically relevant extent. Dose adjustment of either drug is not necessary when tegaserod is combined with dextromethorphan.
Theophylline: Co-administration of tegaserod and theophylline did not affect the pharmacokinetics of theophylline. Dose adjustment of theophylline is not necessary when tegaserod is co-administered.
Digoxin: Concomitant administration of tegaserod reduced peak plasma concentration and exposure of digoxin by approximately 15%.
Warfarin: No effect of concomitant administration of tegaserod on warfarin pharmacokinetics and pharmacodynamics. Dose adjustment of warfarin is not necessary when tegaserod is co-administered.
Oral Contraceptives: No alteration in oral contraceptive medication is necessary when tegaserod is co-administered.
Adult: 12 mg / day in 2 divided doses before meals for 1 - 1