TETRACYCLINE

Product: 
TETRACYCLINE
Formulary: 
Generic Formulary
Category: 
Infections & Infestations
Sub Group: 
ANTIBACTERIALS
International Brand Name: 
Sumycin, Panmycin,Terramycin,Tetracyn
Dosages: 
500MG/ 250 mg
Unit of Packing: 
Tablets/ Capsules
In treatment of: 
Treatment of susceptible infections
Adverse Effects: 
1.Headache, dizziness, intracranial hypertension 2.Aggravates renal & hepatic impairment 3.Nausea 4.Vomiting 5.Epigastric distress 6.Super infection 7.Skin rashes 8.Arrhythmia, Cardiac arrest 9.Neutropenia, Thrombocytopenia 10.Elevated liver enzymes 11.Discoloration of teeth & Retardation of bone growth 12.Esophageal ulceration
Contraiindication: 
Hypersensitive individuals
Special Precaution: 
Renal impairment: 1.Tetracycline aggravates renal impairment & leads to negative nitrogen balance. So avoid use of drug in renal impairment. Hepatic impairment: High dose causes hepato toxicity, so dose adjustments is required & avoid Other precautions: 1.Avoid use together with milk & milk products, Antacids, Cations, Vitamins, Products which contain divalent or trivalent cations 2.Potentiation of action of anticoagulants; so avoid use together 3.Diabetes mellitus, Hyperthyroidism, & Hypertensions
Interaction: 
Antacids (aluminium, calcium, zinc, magnesium), Iron salts, Bismuth salts: Impair absorption of tetracyclines thus reducing its efficacy. Anticoagulants: Increase the hypothrombinemic effects of anti-coagulants. Cimetidine: Decreases GI absorption leading to decreased efficacy of tetracyclines. Digoxin: Increased serum levels leading to digoxin toxicity. Methoxyflurane: Nephrotoxic effects of both increased. Oral contraceptives: Breakthrough bleeding, pregnancy due to decreased efficacy. Penicillins: Efficacy reduced. Food: Dairy products decrease efficacy of tetracyclines. Lab tests: Bacterio-suppressive levels of Demeclocycline persist in both urine and blood for several days after cessation of therapy interfering with culture studies.
Servings: 
Adults: Oral administration of 500mg tablets 6 hourly or 12 hourly as required. Children: 15 to 25mg/kg bodyweight. Maximum dose 50mg/kg. Administer 6hourly or 12 hourly as required Infections of cervix, urethra&rectum caused by Chlamydia trachomatis:2gm daily; orally; in four divided doses for a week. Gonorrhea: Starts with 1.5gm oral administration & then administer 500mg tablets four times daily for four days Syphilis: oral administration of 1-2 gm daily in four divided doses for two weeks Brucellosis: 2gm daily in four divided doses for 28 days (along with streptomycin 1gm for first 21 days) Ulcer caused by H-pylori infection: 2gm daily in four divided doses for 10 - 14 days. Lyme disease: 0.25-0.5gm; orally four times daily for 10 days to One month. Acne: Initial dose-0.5gm to 1gm orally four times daily; maintenance dose 0.12 to 0.5mg daily Malaria: 1 g daily in 2 - 4 divided doses

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