Infections & Infestations
International Brand Name:
In treatment of:
Treatment of susceptible infections
1.Headache, dizziness, intracranial hypertension
2.Aggravates renal & hepatic impairment
8.Arrhythmia, Cardiac arrest
10.Elevated liver enzymes
11.Discoloration of teeth & Retardation of bone growth
1.Tetracycline aggravates renal impairment & leads to negative nitrogen balance. So avoid use of drug in renal impairment.
High dose causes hepato toxicity, so dose adjustments is required & avoid
1.Avoid use together with milk & milk products, Antacids, Cations, Vitamins, Products which contain divalent or trivalent cations
2.Potentiation of action of anticoagulants; so avoid use together
3.Diabetes mellitus, Hyperthyroidism, & Hypertensions
Antacids (aluminium, calcium, zinc, magnesium), Iron salts, Bismuth salts: Impair absorption of tetracyclines thus reducing its efficacy.
Anticoagulants: Increase the hypothrombinemic effects of anti-coagulants.
Cimetidine: Decreases GI absorption leading to decreased efficacy of tetracyclines.
Digoxin: Increased serum levels leading to digoxin toxicity.
Methoxyflurane: Nephrotoxic effects of both increased.
Oral contraceptives: Breakthrough bleeding, pregnancy due to decreased efficacy.
Penicillins: Efficacy reduced.
Food: Dairy products decrease efficacy of tetracyclines.
Lab tests: Bacterio-suppressive levels of Demeclocycline persist in both urine and blood for several days after cessation of therapy interfering with culture studies.
Adults: Oral administration of 500mg tablets 6 hourly or 12 hourly as required.
Children: 15 to 25mg/kg bodyweight. Maximum dose 50mg/kg. Administer 6hourly or 12 hourly as required
Infections of cervix, urethra&rectum caused by Chlamydia trachomatis:2gm daily; orally; in four divided doses for a week.
Gonorrhea: Starts with 1.5gm oral administration & then administer 500mg tablets four times daily for four days
Syphilis: oral administration of 1-2 gm daily in four divided doses for two weeks
Brucellosis: 2gm daily in four divided doses for 28 days (along with streptomycin 1gm for first 21 days)
Ulcer caused by H-pylori infection: 2gm daily in four divided doses for 10 - 14 days.
Lyme disease: 0.25-0.5gm; orally four times daily for 10 days to One month.
Acne: Initial dose-0.5gm to 1gm orally four times daily; maintenance dose 0.12 to 0.5mg daily
Malaria: 1 g daily in 2 - 4 divided doses