TORASEMIDE

Product: 
TORASEMIDE
Formulary: 
Generic Formulary
Category: 
Genito Urinary System
Sub Group: 
DIURETICS
International Brand Name: 
Demadex
Dosages: 
10 MG/20 mg
Unit of Packing: 
Tablets
In treatment of: 
OEDEMA of renal origin
Adverse Effects: 
1. Excessive urination 2. Altered electrolyte balance 3. Diarrhoea 4. Constipation 5. Dizziness 6. Headache 7. Rhinitis 8. Asthenia 9. ECG Abnormality 10. Increased cough 11. Nausea 12. Arthralgia 13. Dyspepsia 14. Sore Throat 15. Myalgia 16. Chest Pain 17. Insomnia 18. Edema 19. Nervousness 20. Ototoxicity
Contraiindication: 
1. Hypersensitivity to Torsemide and other sulfonylurea derivatives 2. Patient with anuria
Special Precaution: 
1. Monitor fluid and electrolyte balance
Interaction: 
Anticoagulants: Activity of anticoagulants may be enhanced. Aminoglycoside antibiotics: Frusemide increases potential for ototoxicity. Cisplatin: Frusemide increases potential for ototoxicity. Digitalis glycosides: Diuretics induced potassium loss may precipitate digitalis toxicity, increased frequency of cardiac arrhythmias. NSAIDs: Effect of frusemide reduced. Lithium: Therapeutic and toxic effects of lithium increased. Metolazone: Profound diuresis and greater than predicted electrolyte loss related to the ability of metolazone to block proximal tubular sodium reabsorption useful in patients refractory to frusemide. Non-depolarizing muscle relaxants: Action of succinylcholine & tubocurarine potentiated by low doses reversed by high doses. Food: Efficacy reduced when administered with food. Propranolol: Plasma propranolol level may be increased. Clofibrate: Increased diuretic responses. Hydantoins: May decrease the diuretic effects.
Servings: 
Adult: Oral: As diuretic 1. In heart failure: 10 - 20 mg once daily if sufficient therapeutic response is not obtained then increases the dose until response is obtained up to 200 mg/ day. 2. In chronic renal failure: 20 mg once daily if sufficient therapeutic response is not obtained then increases the dose until response is obtained up to 200 mg/ day. 3. In hepatic cirrhosis: 5 - 10 mg once daily with potassium sparing antagonist if sufficient therapeutic response is not obtained then increases the dose until response is obtained up to 40 mg/ day. Intravenous: Same as oral dose Hypertension: 5 mg / day if needed dose can be gradually increased to 10mg Children: Not recommended

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