TRIAMCINOLONE

Product: 
TRIAMCINOLONE
Formulary: 
Generic Formulary
Category: 
Endocrine System
Sub Group: 
CORTICOSTEROIDS
International Brand Name: 
Kenolog,Aristocort, Nasacort, Tri-Nasal, Treiderm,Azmacort, Trilone,Volon A, Tricorlone, Triensence
Dosages: 
4 MG/10 MG/ML/40ML/ML
Unit of Packing: 
Tablets
In treatment of: 
Replacement therapy in Adrenal insufficiency
Adverse Effects: 
1.Susceptibility to infection 2.Peptic ulcer 3.Haemorrhage 4.Glycosuria 5.Hyperglycaemia 6.Osteoporosis 7.Atrophy of adrenal cortex(on prolonged therapy) 8.Suppression of adrenocorticotropic hormone 9.Cushing`s syndrome 10.Inhibition of growth in children 11.Amenorrhoea 12.Behavioral disturbances 13.Thromboembolic disorders 14.Myopathy 15.Weakness 16.Lymphocytopenia 17.Muscle wasting 18.Gastrointestinal discomfort 19.Increased appetite 20.Delayed wound healing 21.Headache 22.Euphoria 23.Insomnia 24.Seizures 25.Heart failure 26.Arrhythmias 27.Posterior sub capsular cataract 28.Glaucoma 29.Sodium and fluid retention 30.Hypo kalaemia 31.Increased intracranial pressure
Contraiindication: 
1.Hypersensitivity to the drug 2.Epilepsy 3.Peptic ulcer 4.Tuberculosis 5.Systemic fungal infections 6.Herpes simplex 7.Renal impairment 8.Not to be given intravenously
Special Precaution: 
1.Avoid sudden discontinuation of the drug 2.Monitor vital parameters, therapeutic response and adjust the dosage 3.Use lower dosages as much as possible 4.Osteoporosis 5.Primary glaucoma 6.Primary psychosis and psychoneurosis 7.Recent myocardial infarction 8.Heart failure 9.Diabetes mellitus 10.Hypothyroidism 11.Cirrhosis 12.Stress 13.Sepsis 14.Hypertension 15.Myasthenia gravis 16.Hepatic impairment 17.Non specific Ulcerative colitis 18.Diverticulitis 19.Recent intestinal anastomosis 20.Seizures 21.Thromboembolic disorders
Interaction: 
Barbiturates: Decreases efficacy of triamcinolone. Oral contraceptives: May increase half life and concentration of triamcinolone. Oestrogens: May decrease clearance of triamcinolone. Rifampicin: Decreases efficacy. Triamcinolone effects the action of the following: Anticiholinesterases: Efficacy antagonised in myasthenia gravis. Oral anticoagulants: Altered response. Cyclosporine: Increased cyclosporine efficacy, toxicity may be enhanced. Digitalis glycosides: Increased possibility of toxicity associated with hypokalaemia. Isoniazid: Decreased serum levels of isoniazid. Salicylates: Decreased serum levels of salicylates. Diuretics: May cause increased hypokalaemia and increased hyperglycemia. Non-depolarising muscle relaxants: Altered response. Theophyllines: Altered response of either agent. Lab Tests: Increases serum cholesterol levels. Increases urine glucose levels. Decreases Thyroid I uptake. Decreases T3 serum levels. Decreases serum potassium.
Servings: 
Oral: 4 to 32mg/day as once daily or 2 to 4 divided doses depending up on the severity of the condition. Children: 4 to 12mg/day Adrenal insufficiency: 4 to 12mg/day as once daily or as divided doses depending up on the severity of the condition. Children: 117mcg/kg/day as once daily or as divided doses. Collagen diseases, Tuberculous meningitis: 30 to 48mg/day. Respiratory diseases: 16 to 48mg/day as once daily or as divided doses depending up on the severity of the condition. Malignancies: 16 to 100mg/day as once daily or as divided doses depending up on the severity of the condition. Parenteral: 4 to 32mg/day as once daily or as divided doses I.M.: 40 to 60mg as deep I.M. injection depending up on the severity of the condition. In asthma and hey fever increases the dosage up to 100mg as required by the patient. Intra-articular: 2.5mg to 15mg depending up on the severity of the condition. Intradermal: 0.2 to 0.3ml

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