TOPICAL STEROID PREPARATION
International Brand Name:
Ledrecort ,Azmacort, Kenacort-A ,Kenalog in Oorabase, Nasacort/Nasacort AQ
1.Susceptibility to infection
7.Atrophy of adrenal cortex(on prolonged therapy)
8.Suppression of adrenocorticotropic hormone
10.Inhibition of growth in children
20.Delayed wound healing
27.Posterior sub capsular cataract
29.Sodium and fluid retention
31.Increased intracranial pressure
1.Hypersensitivity to the drug
5.Systemic fungal infections
8.Not to be given intravenously
1.Avoid sudden discontinuation of the drug
2.Monitor vital parameters, therapeutic response and adjust the dosage
3.Use lower dosages as much as possible
6.Primary psychosis and psychoneurosis
7.Recent myocardial infarction
17.Non specific Ulcerative colitis
19.Recent intestinal anastomosis
Barbiturates: Decreases efficacy of triamcinolone.
Oral contraceptives: May increase half life and concentration of triamcinolone.
Oestrogens: May decrease clearance of triamcinolone.
Rifampicin: Decreases efficacy.
Triamcinolone effects the action of the following:
Anticiholinesterases: Efficacy antagonised in myasthenia gravis.
Oral anticoagulants: Altered response.
Cyclosporine: Increased cyclosporine efficacy, toxicity may be enhanced.
Digitalis glycosides: Increased possibility of toxicity associated with hypokalaemia.
Isoniazid: Decreased serum levels of isoniazid.
Salicylates: Decreased serum levels of salicylates.
Diuretics: May cause increased hypokalaemia and increased hyperglycemia.
Non-depolarising muscle relaxants: Altered response.
Theophyllines: Altered response of either agent.
Lab Tests: Increases serum cholesterol levels. Increases urine glucose levels. Decreases Thyroid I uptake. Decreases T3 serum levels. Decreases serum potassium.
Oral: 4 to 32mg/day as once daily or 2 to 4 divided doses depending up on the severity of the condition.
Children: 4 to 12mg/day
Adrenal insufficiency: 4 to 12mg/day as once daily or as divided doses depending up on the severity of the condition.
Children: 117mcg/kg/day as once daily or as divided doses.
Collagen diseases, Tuberculous meningitis: 30 to 48mg/day.
Respiratory diseases: 16 to 48mg/day as once daily or as divided doses depending up on the severity of the condition.
Malignancies: 16 to 100mg/day as once daily or as divided doses depending up on the severity of the condition.
Parenteral: 4 to 32mg/day as once daily or as divided doses
I.M.: 40 to 60mg as deep I.M. injection depending up on the severity of the condition.
In asthma and hey fever increases the dosage up to 100mg as required by the patient.
Intra-articular: 2.5mg to 15mg depending up on the severity of the condition.
Intradermal: 0.2 to 0.3ml