UROKINASE

Product: 
UROKINASE
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
ANTI COAGULANTS THROMBOLYTICS & ANTIPLATLET DRUGS
International Brand Name: 
Abbokinase,Abbokinase Open-Cath
Dosages: 
250000IU/500000IU/75000000IU/ 10000000IU
Unit of Packing: 
Vial
In treatment of: 
Treatment of periphera Arterial Thromboembolism
Adverse Effects: 
1. Haemorrhage 2. Allergic reactions 3. Fever 4. Arrhythmias 5. Hypotension or hypertension 6. Bronchospasm 7. Angioedema 8. Anaphylaxis 9. Urticaria 10. Pruritus 11. Flushing
Contraiindication: 
1. Hypersensitivity to the drug 2. Bleeding disorders 3. Ulcerative wounds 4. In sub acute bacterial endocarditis 5. Severe hypertension 6. Increased capillary permeability 7. Possible internal injuries 8. Cerebrovascular haemorrhage 9. Surgery within 10days 10. 10days postpartum 11. Lumbar puncture 12. Renal impairment 13. Hepatic impairment
Special Precaution: 
1. Renal diseases 2. Liver diseases
Interaction: 
Anticoagulants and antiplatelet agents: Carefully monitor since they may cause bleeding complications.
Servings: 
Pulmonary embolism: 4400 IU/kg I.V. over 10minutes followed by 4400 IU/kg every hour for 12 hours Coronary artery thrombosis: 6000 IU/minute intra arterially in to the coronary artery until maximum opening of artery or up to 2 hours of an average total dose of 500000 IU. Acute myocardial infarction: 2 million IU as I.V. bolus. Alternatively 6000 to 10000 IU/minute intra arterially in to the coronary artery; until maximum opening of artery or up to 2 hours.

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Kayem Pharma

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