VINBLASTINE

Product: 
VINBLASTINE
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
Alkaban, Velban
Dosages: 
10 mg/10 ml
Unit of Packing: 
Vial
In treatment of: 
Treatment of Hodgkin's and non Hodgkin's Lymphoma;Testicular,Lung,Head and Neck,Breast and Renal Carcinomas,Mycosis,Fugodies,Kaposi's Sarcoma,Histiocytosis,Choriocarcinoma,Idiopathic Thrombocytopaenic Purpura
Adverse Effects: 
1. Nausea 2. Vomiting 3. Lowered resistance to infection 4. Bruising or unusual bleeding 5. Anemia 6. Weakness 7. Sore in mouth 8. Taste changes 9. Diarrhea 10. Loss of appetite 11. Visual changes 12. Black, tarry stools 13. Blood in urine or in stool 14. Cough or hoarseness 15. Fever 16. Chills 17. Lower back or side pain 18. Painful or difficult urination 19. Pinpoint red spot on skin 20. Slurred speech 21. Swelling on leg or lower leg 22. Shortness of breath 23. Pulmonary fibrosis 24. Hepatotoxicity 25. Central and peripheral neurotoxicity 26. Stomatitis 27. Disorientation 28. Lethargy 29. Ataxia 30. Thrombocytopenia 31. Leucopenia 32. Bone marrow suppression 33. Alopecia 34. Dermatitis 35. Hypertension 36. Hyperurecemia 37. Cranial nerve damage 38. Ischemic cardiac toxicity 39. Dyspnoea 40. Bone and tumor pain
Contraiindication: 
1. Hypersensitivity to the drug 2. Severe bone marrow suppression 3. Bacterial infection4.recent immunizations
Special Precaution: 
1. Hepatic impairment 2. Bronchospasm 3. Extravasations
Interaction: 
Mitomycin: Acute shortness of breath and severe bronchospasm. Phenytoin: Combination chemotherapy (including vinblastine) may reduce plasmalevels and increase seizure activity. Erythromycin: Severe myalgia, neutropenia and constipation.
Servings: 
Intravenous- Adult- 0.1-0.5mg/kg every 7 to 10 days or 3.7mg/metre square weekly. Children- 2.5mg/metre square as a single dose every week.

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