VINCRISTINE

Product: 
VINCRISTINE
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
Oncovin
Dosages: 
1 mg/ml
Unit of Packing: 
Inj-1ml
In treatment of: 
Treatment of acute Leukemia
Adverse Effects: 
1. Nausea 2. Vomiting 3. Lowered resistance to infection 4. Bruising or unusual bleeding 5. Anemia 6. Weakness 7. Sore in mouth 8. Taste changes 9. Diarrhea 10. Loss of appetite 11. Visual changes 12. Black, tarry stools 13. Blood in urine or in stool 14. Cough or hoarseness 15. Fever 16. Chills 17. Lower back or side pain 18. Painful or difficult urination 19. Pinpoint red spot on skin 20. Slurred speech 21. Swelling on leg or lower leg 22. Shortness of breath 23. Pulmonary fibrosis 24. Intestinal necrosis 25. Hypotension 26. Stomatitis 27. Disorientation 28. Lethargy 29. Ataxia 30. Thrombocytopenia 31. Leucopenia 32. Bone marrow suppression 33. Hypertension 34. Acute Bronchospasm 35. Reversible alopecia 36. Phlebitis 37. Cellulitis at the site of injection
Contraiindication: 
1. Hypersensitivity to the drug 2. Demyelinating form of Charcot-Marie-Tooth syndrome 3. Recent radiation therapy
Special Precaution: 
1. Infection 2. Neuromuscular disease 3. Leucopenia 4. Pulmonary disorder 5. Leukemia 6. Radiation therapy 7. Extravasations 8. Treatment with neurotoxic drug 9. Recent vaccination
Interaction: 
Digoxin: Decreased plasma digoxin levels and renal excretion. L-asparaginase: Hepatic clearance of vincristine is reduced if L-asparaginase is administered first. Thus to minimise toxicity, vincristine should be given 12 to 24 hours before administering L- asparaginase. Mitomycin-C: Acute pulmonary reaction may occur. Phenytoin: Reduced phenytoin plasma levels.
Servings: 
Intravenous- Adult- 10 - 30 mcg/kg or 0.4 - 1.4mg/metre square /weekly Children- 1.5 - 2 mg/metre square/weekly

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