International Brand Name:
1. Gastrointestinal disturbances
2. Hypo kalaemia
4. Carbohydrate intolerance
5. Elevated lipid levels
6. Hyper urecaemia
8. Rarely other electrolyte imbalance
1. Hyper uricaemia
2. Hyper calcaemia
3. Renal impairment
4. Hepatic impairment
5. Hypersensitivity to the drug
6. Hyper sensitivity to sulfonamides
7. Fluid and electrolyte imbalance
8. Addison`s disease
1. Renal and hepatic diseases
2. Hyper urecaemia and Gout
3. Diabetes mellitus
4. Monitor and correct Fluid and electrolyte imbalance
6. Hyper calcaemia
7. Systemic lupus erythematosus
8. Prostatic hypertrophy
Cholestyramine & Colestipol: decrease absorption of Xipamide.
Diazoxide: Additive action-may cause hyperglycemia, hyperuricaemia and hypotension.
Digitalis: Diuretic induced hypokalaemia may precipitate digitalis toxicity.
Lithium: Xipamide potentiates therapeutic and toxic effects by decreasing its renal excretion.
Frusemide: Synergy leading to profound diuresis and greater than predicted electrolyte loss.
Non depolarizing muscle relaxants: Diuretic induced hypokalaemia enhances efficacy.
Sulfonylureas: Efficacy decreased due to Xipamaide induced glucose intolerance.
Propantheline: Bioavailability of Xipamide increased.
Metoclopramide: Bioavailability of Xipamide decreased.
NSAIDs: Natriuretic effect of Xipamide decreased.
Hypertension: 20mg once daily in the morning. Increased to 40mg 0nce daily if required.
Oedema: 40mg once daily. Reduced gradually; based on patient`s response up to 20mg.
Maximum dose: 80mg.