Generic Formulary
Infections & Infestations
Sub Group: 
International Brand Name: 
300MG/100 mg
Unit of Packing: 
Tablets/ Capsules
In treatment of: 
Management of HIV infection and prevention of Maternal-foetal HIV transmission,short term management of HIV infection
Adverse Effects: 
1. Nausea 2. Vomiting 3. Diarrhoea 4. Anorexia 5. Headache 6. Dizziness 7. Anaemia 8. Agranulocytosis 9. Thrombocytopenia 10. Myalgia 11. Rash
1. Hypersensitivity to Zidovudine
Special Precaution: 
1. Renal impairment 2. Hepatic dysfunction (Hepatitis, hepatomegaly) 3. Patient with severe bone marrow suppression 4. Pre existing anaemia 5. Granulocytopenia
Dapsone, Pentamidine, Amphotericin B, Flucytosine, Vincristine, Vinblastine, Adriamycin, Interferon: Concomitant use with drugs that are nephrotoxic, cytotoxic or myelosuppressive may increase toxicity risk. Trimethoprim:The serum levels of Zidovudine and its metabolite may be increased. Probenecid:Toxicity of either drug may be potentiated. Acetaminophen: Increased incidence of granulocytopenia. Acyclovir: Concomitant use may result in neurotoxicity. Phenytoin: Altered phenytoin levels. Zidovudine clearance decreased by phenytoin.
Adult: 600 mg / day in 2 - 3 divided dose Asymptomatic HIV infection and for preventing HIV transmission from mother to fetus: 100 mg 5 times daily; should be taken every 4 hours. Children: 720 mg / sq.metre / day in 4 divided dose in equal interval

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